Journal
PSYCHOPHARMACOLOGY
Volume 212, Issue 4, Pages 475-484Publisher
SPRINGER
DOI: 10.1007/s00213-010-1973-x
Keywords
Anxiety; Amygdala; GABA C receptors; GABA rho receptors; Elevated plus-maze; Corticosterone; Intercalated paracapsular islands
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Funding
- Computing Unit of the Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico
- Direccion de Asuntos del Personal Academico de la Universidad Nacional Autonoma de Mexico [IN200508]
- Mexican Research Council [CONACyT 194963]
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Accumulating evidence for the presence of GABA(A) rho receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. This work was conducted to study whether GABA(A) rho receptors may have a putative role in the amygdaloid modulation of fear and anxiety. It was found that the bilateral intra-amygdaloid administration (6-240 pmol/side) of (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a selective GABA(A) rho receptor antagonist, reduced dose-dependently the exploration of the open arms of the elevated plus-maze without affecting locomotion and increased the plasma levels of corticosterone. In contrast, bicuculline in the dose range used (1.8-60 pmol/side) induced seizures, but had no effects on the exploration of the maze. It is suggested that GABA(A) rho receptors may have a role in the amygdaloid modulation of fear and anxiety.
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