Journal
BIOMEDICAL OPTICS EXPRESS
Volume 6, Issue 10, Pages 4179-4190Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.6.004179
Keywords
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Funding
- ERC [242991]
- Imperial College Junior Research Fellowship
- NIHR-HTD [240]
- National Institute for Health Research [HTD 240] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [HTD 240] Funding Source: National Institutes of Health Research (NIHR)
- European Research Council (ERC) [242991] Funding Source: European Research Council (ERC)
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Intraoperative monitoring of tissue oxygen saturation (StO(2)) has potentially important applications in procedures such as organ transplantation or colorectal surgery, where successful reperfusion affects the viability and integrity of repaired tissues. In this paper a liquid crystal tuneable filter-based multispectral imaging (MSI) laparoscope is described. Motion-induced image misalignments are reduced, using feature-based registration, before regression of the tissue reflectance spectra to calculate relative quantities of oxy- and deoxyhaemoglobin. The laparoscope was validated in vivo, during porcine abdominal surgery, by making parallel MSI and blood gas measurements of the small bowel vasculature. Ischaemic conditions were induced by local occlusion of the mesenteric arcade and monitored using the system. The MSI laparoscope was capable of measuring StO(2) over a wide range (30-100%) with a temporal error of +/- 7.5%. The imager showed sensitivity to spatial changes in StO(2) during dynamic local occlusions, as well as tracking the recovery of tissues post-occlusion. (C)2015 Optical Society of America
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