Journal
PSYCHONEUROENDOCRINOLOGY
Volume 38, Issue 5, Pages 603-611Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2012.12.025
Keywords
HPA axis; Cortisol; Pituitary; Glucocorticoid; Psychosis; First episode psychosis; Schizophrenia
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Funding
- South London and Maudsley NHS Foundation Trust Et Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health
- Academy of Medical Sciences
- Wellcome Trust
- British Heart Foundation
- ECNP Young Scientist Award
- Academy of Medical Sciences (AMS) [AMS-SGCL5-Mondelli] Funding Source: researchfish
- National Institute for Health Research [CL-2008-17-005] Funding Source: researchfish
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Up to now studies on hypothalamic pituitary adrenal (HPA) axis activity in psychosis have shown inconsistent findings. These inconsistencies have been often ascribed to confounding effects of long duration of illness and chronic treatment with psychotropic medications of the subjects studied (chronic psychosis). In the last years, several studies have focused on the study of subjects at their first episode of psychosis to overcome these possible confounders. The aim of this paper was to review the literature investigating HPA axis activity in first episode psychosis. Findings from these studies support the presence of HPA axis hyperactivity and a blunted HPA axis response to stress at the onset of psychosis. Possible biological pathways linking these HPA axis abnormalities to the development of psychosis are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
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