Journal
PSYCHOMETRIKA
Volume 78, Issue 3, Pages 396-416Publisher
SPRINGER
DOI: 10.1007/S11336-012-9294-0
Keywords
functional MRI; blood oxygen level dependent; first-level analysis; higher level analysis; sources of noise
Categories
Funding
- National Center for Research Resources [P41-RR14075, R01 RR16594, P41-009874]
- National Center for Research Resources (NCRR BIRN Morphometric Project) [BIRN002]
- National Center for Research Resources (Functional Imaging Biomedical Informatics Research Network (FBIRN)) [U24 RR021382]
- National Institute for Biomedical Imaging and Bioengineering [R01 EB001550, R01EB006758]
- Department of Energy [DE-F02-99ER62764-A012]
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Functional magnetic resonance imaging (fMRI) is a noninvasive method for measuring brain function by correlating temporal changes in local cerebral blood oxygenation with behavioral measures. fMRI is used to study individuals at single time points, across multiple time points (with or without intervention), as well as to examine the variation of brain function across normal and ill populations. fMRI may be collected at multiple sites and then pooled into a single analysis. This paper describes how fMRI data is analyzed at each of these levels and describes the noise sources introduced at each level.
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