Journal
PSYCHOLOGICAL MEDICINE
Volume 43, Issue 4, Pages 699-709Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001675
Keywords
Augmentation; depression; exercise; insomnia; physical activity; sleep
Categories
Funding
- National Institute for Mental Health [NIMH 1-R01-MH067692-01]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Agency for Healthcare Research and Quality (AHRQ)
- Corcept Therapeutics, Inc.
- Cyberonics, Inc.
- Merck
- NARSAD
- NIMH
- National Institute on Drug Abuse
- Naurex
- Novartis
- Pharmacia Upjohn
- Predix Pharmaceuticals (Epix)
- Solvay Pharmaceuticals, Inc.
- Targacept
- Valient
- Abbott Laboratories, Inc.
- Abdi Ibrahim
- Akzo (Organon Pharmaceuticals Inc.)
- Alkermes
- Astra-Zeneca
- Bristol-Myers Squibb Company
- Cephalon, Inc.
- Evotec
- Fabre Kramer Pharmaceuticals, Inc.
- Forest Pharmaceuticals
- GlaxoSmithKline
- Janssen Pharmaceutica Products
- Libby
- LP
- Johnson Johnson PRD
- Eli Lilly Company
- Meade Johnson
- Medtronic
- Neuronetics
- Otsuka Pharmaceuticals
- Parke-Davis Pharmaceuticals, Inc.
- Pfizer Inc.
- Sepracor
- SHIRE Development
- Sierra
- Tal Medical/Puretech
- Transcept
- VantagePoint
- Wyeth-Ayerst Laboratories
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Background. Sleep disturbances are persistent residual symptoms following remission of major depressive disorder (MDD) and are associated with an increased risk of MDD recurrence. The purpose of the current study was to examine the effect of exercise augmentation on self-reported sleep quality in participants with non-remitted MDD. Method. Participants were randomized to receive selective serotonin reuptake inhibitor (SSRI) augmentation with one of two doses of exercise : 16 kilocalories per kilogram of body weight per week (KKW) or 4 KKW for 12 weeks. Depressive symptoms were assessed using the clinician-rated Inventory of Depressive Symptomatology (IDS-C). The four sleep-related items on the IDS-C (Sleep Onset Insomnia, Mid-Nocturnal Insomnia, Early Morning Insomnia, and Hypersomnia) were used to assess self-reported sleep quality. Results. Significant decreases in total insomnia (p<0.0001) were observed, along with decreases in sleep onset, mid-nocturnal and early-morning insomnia (p's <0.002). Hypersomnia did not change significantly (p=0.38). Changes in total, mid-nocturnal and early-morning insomnia were independent of changes in depressive symptoms. Higher baseline hypersomnia predicted a greater decrease in depression severity following exercise treatment (p=0.0057). No significant moderating effect of any baseline sleep on change in depression severity was observed. There were no significant differences between exercise treatment groups on total insomnia or any individual sleep item. Conclusions. Exercise augmentation resulted in improvements in self-reported sleep quality in patients with non-remitted MDD. Given the prevalence of insomnia as a residual symptom following MDD treatment and the associated risk of MDD recurrence, exercise augmentation may have an important role in the treatment of MDD.
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