Journal
PSYCHOLOGICAL MEDICINE
Volume 43, Issue 10, Pages 2027-2036Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712002656
Keywords
Cognition; endophenotype; genetics; GWAS; schizophrenia
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Medical Research Council [G0700704B, MR/K026992/1, G0700704] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: Medline
- Medical Research Council [G0700704, MR/K026992/1] Funding Source: Medline
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0700704] Funding Source: UKRI
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Cognitive deficits are core to the disability associated with many psychiatric disorders. Both variation in cognition and psychiatric risk show substantial heritability, with overlapping genetic variants contributing to both. Unsurprisingly, therefore, these fields have been mutually beneficial : just as cognitive studies of psychiatric risk variants may identify genes involved in cognition, so too can genome-wide studies based on cognitive phenotypes lead to genes relevant to psychiatric aetiology. The purpose of this review is to consider the main issues involved in the phenotypic characterization of cognition, and to describe the challenges associated with the transition to genome-wide approaches. We conclude by describing the approaches currently being taken by the international consortia involving many investigators in the field internationally (e. g. Cognitive Genomics Consortium; COGENT) to overcome these challenges.
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