Journal
PSYCHOLOGICAL MEDICINE
Volume 40, Issue 1, Pages 1-4Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291709005558
Keywords
Cortisol; depression; glucocorticoid receptor; HPA axis
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Funding
- Medical Research Council Funding Source: Medline
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Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk Of future illness. Persistent hypersecretion of cortisol in individuals vulnerable to depression also has implications for the medical co-morbidities associated with mood disorder. Pharmacological treatments targeted at the HPA axis represent a novel approach to the management of depression and its complications; however, a better understanding of the Molecular basis of HPA axis dysfunction in depressed patients will be needed before this promise can be fulfilled.
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