4.7 Article

Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects

Journal

PSYCHOLOGICAL MEDICINE
Volume 39, Issue 10, Pages 1657-1665

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291709005388

Keywords

Dysbindin; P1578; rs1018381; schizophrenia; schizotypy

Funding

  1. Federal Ministry of Education and Research (Brain Imaging Centre West) [01GO0204]

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Background. Schizophrenia is a complex disorder with a high heritability. Family members have an increased risk not only for schizophrenia per se but also for schizophrenia spectrum disorders. Impairment of neuropsychological functions found in schizophrenia patients are also frequently observed in their relatives. The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated Vulnerability genes for schizophrenia. In addition, this gene has been shown to modulate general cognitive abilities both in healthy subjects and in patients with schizophrenia. Method. In a sample of 521 healthy subjects we investigated an association between the DTNBP1 genotype [single nucleotide polymorphism (SNP) rs1018381], personality traits [using the NEO Five-Factor Inventory (NEO-FFI) and the Schizotypal Personality Questionnaire - Brief Version (SPQ-B)] and cognitive function (estimated IQ, verbal fluency, attention, working memory and executive function). Results. Significantly lower scores on the SPQ-B (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) in carriers of the A-risk allele were detected. There were no differences in any of the cognitive variables between groups. Conclusions. The results indicate that genetic variation of the DTNBP1 genotype might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level.

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