Depression, cytokines, and pancreatic cancer

Objective Mediating mechanisms of a 12-week group-based exercise intervention on cancer survivors' quality of life (QoL) were examined to inform future exercise intervention development. Methods Two hundred nine cancer survivors >= 3 months posttreatment (57% breast cancer) aged 49.5 (+/- 10.4) years were assigned to physical exercise (n = 147) or wait-list control (n = 62). QoL, fatigue, emotional distress, physical activity, general self-efficacy and mastery were assessed at baseline and post-intervention using questionnaires. Path analysis was conducted using Mplus to explore whether improved physical activity, general self-efficacy and mastery mediated the effects of exercise on fatigue and distress and consequently QoL. Results The intervention was associated with increased physical activity (beta = 0.46, 95% confidence interval (CI) = 0.14;0.59), general self-efficacy (beta = 2.41, 95%CI = 0.35;4.73), and mastery (beta = 1.75, 95%CI = 0.36;2.78). Further, the intervention had both a direct effect on fatigue (beta = -1.09, 95%CI = -2.12;0.01), and an indirect effect (beta = -0.54, 95%CI = -1.00;-0.21) via physical activity (beta = -0.29, 95%CI = -0.64;-0.07) and general self-efficacy (beta = -0.25, 95%CI = -0.61;-0.05). The intervention had a borderline significant direct effect on reduced distress (beta =-1.32, 95%CI =-2.68;0.11), and a significant indirect effect via increased general self-efficacy and mastery (beta =-1.06, 95%CI =-1.89;-0.38). Reductions in fatigue (beta =-1.33, 95%CI =-1.85;-0.83) and distress (beta =-0.86, 95%CI =-1.25;-0.52) were associated with improved QoL. Further, increased physical activity was directly associated with improved QoL (beta = 3.37, 95%CI = 1.01;5.54). Conclusion The beneficial effect of group-based physical exercise on QoL was mediated by increased physical activity, general self-efficacy and mastery, and subsequent reductions in fatigue and distress. In addition to physical activity, future interventions should target self-efficacy and mastery. This may lead to reduced distress and fatigue, and consequently improved QoL of cancer survivors. Copyright (c) 2013 John Wiley & Sons, Ltd.