Journal
PSYCHO-ONCOLOGY
Volume 21, Issue 11, Pages 1141-1148Publisher
WILEY
DOI: 10.1002/pon.3196
Keywords
cancer; oncology; cognition; brain vulnerability; chemotherapy
Funding
- National Cancer Institute, Bethesda, MD, USA [R01 CA87845, R01 CA101318, R01 CA129769, U54 CA132378]
- Starr Foundation
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Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. By using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. An impressive body of research supports the hypothesis that a subgroup of patients is vulnerable to post-treatment cognitive changes, although not exclusively related to chemotherapy. Further, imaging and animal model studies provide accumulating evidence of putative mechanisms for chemotherapy-induced cognitive change. Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging. Copyright (c) 2012 John Wiley & Sons, Ltd.
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