Journal
PSYCHO-ONCOLOGY
Volume 22, Issue 1, Pages 212-219Publisher
WILEY-BLACKWELL
DOI: 10.1002/pon.2041
Keywords
salpingo-oophorectomy; BRCA1; BRCA2; psychological distress; health-related quality of life
Funding
- Canadian Institutes of Health Research
- Toronto Ovarian Cancer Research Network
- Kristi Piia Callum Memorial Fellowship in Ovarian Cancer Research
- University of Toronto Open Fellowship
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Objectives The objective of this study was to measure the impact of prophylactic salpingo-oophorectomy on health-related quality of life and psychological distress in women. Methods Women who underwent prophylactic salpingo-oophorectomy between August 20, 2003 and June 26, 2008 because of a BRCA1 or BRCA2 mutation were invited to participate. Participants completed three questionnaires (SF-12 (R) Health Survey, Brief Symptom Inventory and the Impact of Events Scale) before prophylactic surgery and again 1?year after surgery. Measures of health-related quality of life, of general psychological distress and of ovarian cancer worry before and after surgery were compared. Results Few women who underwent salpingo-oophorectomy experienced a worsening in physical or mental health functioning after salpingo-oophorectomy. On average, women experienced less ovarian cancer-specific worry after surgery; 34.3% experienced moderate to severe ovarian cancer-specific distress before surgery, compared with 18.6% after surgery. Conclusions For most women, physical and mental health-related quality of life did not deteriorate after prophylactic salpingo-oophorectomy, and they were less worried about ovarian cancer. A subset of women continued to experience moderate to severe cancer-specific distress. Identification of these women is important in order to provide continued counseling and support. Copyright (c) 2011 John Wiley & Sons, Ltd.
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