Synthesis and antimicrobial activity of α-aminophosphonates containing chitosan moiety

A novel series of alpha-aminophosphonates containing chitosan moiety was obtained in high yields from reactions of chitosan with aromatic aldehydes and triphenylphosphite in the presence of lithium perchlorate as a catalyst. The structures of the synthesized compounds were confirmed by IR and H-1 NMR spectral data. Compounds (1-4) showed high antimicrobial activities against Escherichia coli (NCIM2065), Serratia marcescens, Enterobacter cloacae, Shigella dysenteriae, Salmonella enterica and Proteus vulgaris as Gram-negative bacteria, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Candida albicans as a fungus, at low concentrations (2.5-10 mg/mL). (C) 2014 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.