Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 283, Issue -, Pages 64-66Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2018.09.001
Keywords
Magnetoencephalography (MEG); Ketamine; Depression
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002857, ZICMH002889] Funding Source: NIH RePORTER
- Intramural NIH HHS [ZIA MH002857-14, ZIA MH002857] Funding Source: Medline
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Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. A significant difference in peak gamma power was seen in the depressed ketamine responders versus non-responders. These results implicate AMPA throughput in ketamine's mechanism of antidepressant action.
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