Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 222, Issue 1-2, Pages 114-117Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2014.02.005
Keywords
Bipolar disorder; Magnetic resonance imaging; Neurodevelopment
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Funding
- Japanese Society for the Promotion of Science, Health and Labour Sciences Research Grants [H23-Seishin-Ippan-002, H23-Seishin-Ippan-009]
- Research Group For Schizophrenia, Japan
- JSPS Asian Core Program
- NHMRC [628386]
- NARSAD
- Grants-in-Aid for Scientific Research [26461739, 22591275] Funding Source: KAKEN
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This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar l disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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