Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 222, Issue 1-2, Pages 67-74Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2014.02.004
Keywords
H-1-MRS; OCD; Pediatric; White matter; Psychotropic-naive; Brain
Categories
Funding
- Ontario Mental Health Foundation
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- NSERC Discovery Grant
Ask authors/readers for more resources
Obsessive-compulsive disorder (OCD) has a typical onset during childhood or adolescence. Although recent in-vivo proton magnetic resonance spectroscopy (H-1-MRS) studies report gray matter metabolite abnormalities in children and adolescents with OCD, there are no existing H-1-MRS studies that measure white matter (WM) metabolite levels in this population. In the present study, we measured metabolite levels in the left and right prefrontal WM (LPFWM and RPFWM, respectively) of psychotropic-naive children and adolescents with OCD (LPFWM: N = 15, mean age 13.3 +/- 2.4 years; right RPFWM: N = 14, mean age 13.0 +/- 2.3 years) and healthy controls (LPFWM: N = 17, mean age 11.8 +/- 2.7 years; RPFWM: N = 18, mean age 12.2 perpendicular to 2.8 years). Spectra were acquired using a 3T single voxel PRESS sequence (1.5 Chi 2.0 Chi 2.0 cm(3)). When age and sex effects were controlled, OCD patients had higher levels of RPFWM choline and N-acetyl-aspartate (NAA). In addition, RPFWM levels of NAA, creatine and myoinositol were positively and significantly correlated with severity of OCD symptoms. In summary, this is the first published study of WM metabolite levels in children and adolescents with OCD. Our preliminary findings lend further support to the previous findings of WM abnormalities in OCD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available