Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 221, Issue 3, Pages 173-178Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2014.01.007
Keywords
Magnetic resonance imaging; Bipolar disorder; Basal ganglia; Shape analysis; Volumetry; Psychomotor performance
Categories
Funding
- Swedish Medical Research Council [K2011-61X-14647-09-3, K2010-61X-21569-01-1, K2010-61P-21568-01-4]
- Swedish Foundation for Strategic Research
- Swedish Brain Foundation
- Swedish Federal Government under the LUA/ALF [ALF 20100305, ALFGBG-142041]
Ask authors/readers for more resources
We hypothesized that psychomotor disturbances in patients with bipolar disorder are associated with morphometric changes in functionally specific regions of the basal ganglia and thalamus. We used structural magnetic resonance imaging and vertex-based morphometry to investigate whether psychomotor performance is associated with changes in volume and shape in euthymic subjects with bipolar disorder (n=27) compared with matched healthy controls (n=27). We saw no significant differences between age- and sex-matched groups in motor performance. We found a statistically significant group difference in the shape of the right putamen in the absence of psychomotor disturbances. There was an association between shape and motor performance in controls that was lacking in patients. We conclude that euthymic subjects with bipolar disorder without psychomotor disturbances show shape changes in regions of the right putamen that contribute to executive functions and motor function. It may be that other brain regions sustain the psychomotor functions that produce nearly identical motor performance in both groups. (C) 2014 Elsevier Ireland Ltd. All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available