Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 214, Issue 2, Pages 94-101Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2013.06.008
Keywords
Schizophrenia; Independent component analysis; Cortical thickness; Default mode network; Central executive network; Salience network
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Funding
- Instituto de Salud Carlos III [PI 07/0258]
- N. Pujol grant Rio Hortega IDIBAPS
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Although working memory is known to be impaired in schizophrenia the anatomical and functional relationships underlying this deficit remain to be elucidated. A combined imaging approach involving functional and structural magnetic resonance techniques was used, applying independent component analysis and surface-based morphometry to 14 patients with schizophrenia and 14 healthy controls. Neurocognitive functioning was assessed by a neuropsychological test battery that measured executive function It was hypothesized that working memory dysfunctional connectivity in schizophrenia is related to underlying anatomical abnormalities. Patients with schizophrenia showed cortical thinning in the left inferior frontal gyms and insula, which explained 57% of blood oxygenation level-dependent signal magnitude in functional magnetic resonance imaging in the central executive network (lateral prefrontal and parietal cortex) over-activation and default mode network (anterior and posterior cingulate) deactivation. No structure-function relationship emerged in the healthy control group. The study provides evidence to suggest that dysfunctional activation/deactivation patterns in schizophrenia may be explained in terms of underlying gray matter deficits. (C) 2013 Elsevier Ireland Ltd. All rights reserved
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