Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 213, Issue 2, Pages 99-107Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2013.04.001
Keywords
Functional magnetic resonance imaging (fMRI); Affect recognition; Face processing; Social functioning; Social skills; Neuroplasticity treatment
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Funding
- NIMH BRDG-SPAN grant
- NARSAD Sidney R. Baer, Jr. Foundation Young Investigator Award
- NIMH [MH71746, MH68725-02]
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Both cognitive and social-cognitive deficits impact functional outcome in schizophrenia. Cognitive remediation studies indicate that targeted cognitive and/or social-cognitive training improves behavioral performance on trained skills. However, the neural effects of training in schizophrenia and their relation to behavioral gains are largely unknown. This study tested whether a 50-h intervention which included both cognitive and social-cognitive training would influence neural mechanisms that support social ccognition. Schizophrenia participants completed a computer-based intervention of either auditory-based cognitive training (AT) plus social-cognition training (SCT) (N=11) or non-specific computer games (CG) (N=11). Assessments included a functional magnetic resonance imaging (fMRI) task of facial emotion recognition, and behavioral measures of cognition, social cognition, and functional outcome. The fMRI results showed the predicted group-by-time interaction. Results were strongest for emotion recognition of happy, surprise and fear: relative to CG participants, AT+SCT participants showed a neural activity increase in bilateral amygdala, right putamen and right medial prefrontal cortex. Across all participants, pre-to-post intervention neural activity increase in these regions predicted behavioral improvement on an independent emotion perception measure (MSCEIT: Perceiving Emotions). Among AT+SCT participants alone, neural activity increase in right amygdala predicted behavioral improvement in emotion perception. The findings indicate that combined cognition and social-cognition training improves neural systems that support social-cognition skills. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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