Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 201, Issue 2, Pages 120-127Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2011.07.001
Keywords
ADHD; Dorsal anterior cingulate cortex; Default-mode network; Development; Resting-state fMRI; Functional connectivity
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Funding
- National Science and Technology Foundation of China [2007BAI17B03]
- Special Public Sector Research Foundation for Health and Medicine of China [200802073]
- National High Technology Program of China (863) [2008AA02Z405]
- National Natural Sciences Foundation of China [30970802, 81020108022, 81000593]
- State Key Laboratory of Cognitive Neuroscience and Learning
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A previous study indicated that adults with attention deficit hyperactivity disorder (ADHD) had a decreased anti-correlation between the dorsal anterior cingulate cortex (dACC) and the default mode network (DMN). In this study, we investigated whether children with ADHD also show a decreased anti-correlation between the dACC and the DMN. We also explored the developmental characteristics of the resting-state functional connectivity (RSFC) of the dACC with the DMN in children with ADHD. Resting-state functional magnetic resonance imaging scans were obtained from a 31 scanner in 19 drug-naive boys with ADHD and 23 controls. Compared with normal controls, the dACC in boys with ADHD showed a significantly decreased negative RSFC with the DMN, including the dorsomedial prefrontal cortex and the posterior cingulate cortex. The RSFC strength between the dACC and the posterior cingulate cortex showed a significantly negative correlation with age in normal controls, but not in boys with ADHD. This decreased anti-correlation may suggest an abnormal balance or interaction between attentional and intrinsic thoughts. Our age-related analysis suggested an abnormal development pattern of the dACC-DMN interaction in ADHD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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