Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 191, Issue 1, Pages 80-83Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2010.09.002
Keywords
Diffusion tensor imaging; Fractional anisotropy; Superior longitudinal fasciculus
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Funding
- National Natural Science Foundation of China [81071099]
- Liaoning Science and Technology Foundation [2008225010-14]
- National Institution of Health [K01MH086621]
- National Alliance for Research on Schizophrenia and Depression
- Klingenstein Foundation
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Convergent studies have implicated white matter abnormalities in the pathophysiology of major depressive disorder (MDD). In this study, diffusion tensor imaging (DTI) was used to examine white matter abnormalities in 23 single-episode, medication-naive MDD participants versus 21 healthy control participants. Voxel-based analysis was used to investigate whole brain white matter abnormalities in the MDD group. Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MOD group compared with the healthy group. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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