Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 181, Issue 1, Pages 30-35Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2009.07.010
Keywords
Anterior cingulate cortex; Inhibition; Negative priming; Functional magnetic resonance imaging
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Funding
- National Institute of Mental Health [MH59259]
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The present study used functional magnetic resonance imaging to examine neural correlates of inhibitory dysfunction in individuals diagnosed with major depressive disorder (MDD). Twelve MDD participants and 12 never-depressed controls completed the negative affective priming (NAP) task in the scanner. Results indicated that, in depressed participants, increased activation in the rostral anterior cingulate cortex (rACC) is associated with inhibition of negative, but not positive, words; in contrast, in nondepressed participants, inhibition of positive, but not negative, words is associated with increased activation in the rACC. These findings indicate that abnormalities in neural function, especially in the rACC, may underlie difficulties experienced by depressed individuals in inhibiting negative thoughts. These results underscore the importance of continuing to examine the relation between cognitive and neural functioning in depression in order to gain a broader and more integrative understanding of this disorder. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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