Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 184, Issue 1, Pages 38-48Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2010.06.008
Keywords
Tractography; White matter hyperintensities; Fractional anisotropy; Apparent diffusion coefficient; Magnetization transfer ratio
Categories
Funding
- Danish National Research Foundation
- Danish Medical Research Council
- Research Fund of the Central Denmark Region
- Eli Lilly Psychiatric Research Foundation
- A.P. Moller Foundation for the Advancement of Medical Science
- Eli and Egon Larsen Foundation
- Worzner Foundation
- AstraZeneca
- Danish Psychiatric Society
- Helga and Peter Korning Foundation
- Jacob and Olga Madsen Foundation
- Dr. Pout M. Frgeman Foundation
- Dr. K. Rasmussen Foundation
- Eilif Trier-Hansen and Ane Trier-Hansen Foundation
- Einar Geert-Jorgensen and Ellen Geert-Jorgensen Research Fund
- Fund for Research in Mental Illness, Psychiatric Research Fund
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Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of major depression (MD). We aimed to describe the impact of WMLs on white matter pathways in MD using diffusion tensor imaging (DTI) and magnetization transfer imaging. As a novel approach, we used DTI tractography to assess pathways intersected by WMLs. We examined 22 patients with late-onset MD and 22 age- and gender-matched controls. Parametric maps of fractional anisotropy (FA), apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) were obtained to describe tissue integrity. The association between depression severity and the tract-specific localization of WMLs was analyzed on a voxel-by-voxel basis. We showed a significant positive association between depression severity and fiber tracts intersected by WMLs in the left superior longitudinal fasciculus and the right uncinate fasciculus. In both groups, WMLs had significantly lower FA and MTR, and higher ADC than both the tracts they intersected and the normal-appearing white matter (NAWM). In turn, the tracts intersected by WMLs had significantly lower FA and higher ADC than the NAWM. In conclusion, depression severity correlates with the tract-specific localization of WMLs. WMLs have a pronounced effect on white matter integrity in the pathways they intersect. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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