Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 181, Issue 3, Pages 174-182Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2009.11.003
Keywords
fMRI; Cocaine; Working memory; Thalamus; Treatment response
Categories
Funding
- National Institute on Drug Abuse [P50DA009262, K02DA00403]
- CCTS/CRU [UL1 RR024148]
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Functional magnetic resonance imaging (fMRI) studies of early abstinence cocaine users offer information about the state of the brain when most cocaine users seek treatment This study examined the relationship between pretreatment brain function and subsequent treatment response in 19 treatment-seeking early abstinence cocaine-dependent (CD) subjects. These subjects and 14 non-drug-using control subjects underwent fMRI while performing a working memory task with three levels of difficulty. CD subjects were then randomized to treatment studies. Results showed CD subjects had significantly lower (random effects, corrected for multiple comparisons) brain activation in caudate, putamen, cingulate gyrus, middle and superior frontal gyri, inferior frontal gyrus pars triangularis and pars opercularis, precentral gyrus, and thalamus compared with non-drug-using controls. Within CD subjects, thalamic activation significantly correlated with treatment response. This study shows CD subjects in early abstinence have alterations of brain function in frontal, striatal, and thalamic brain regions known to be part of a circuit associated with motor control, reward, and cognition. Subjects with pretreatment thalamic deactivation showed the poorest treatment response, possibly related to thalamic involvement in mesocortical and mesolimbic dopamine projections. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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