Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 171, Issue 3, Pages 155-165Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2008.03.010
Keywords
Anhedonia; Dorsomedial prefrontal cortex; Ventromedial prefrontal cortex; Cerebellum; FDG-PET; Schizophrenia
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Funding
- Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea [A050495]
- Korea Health Promotion Institute [A050495] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Anhedonia, as a deficit symptom, may be associated with default-mode hypofrontality in schizophrenia. To explore whether trait anhedonia in schizophrenia pertains to altered hypofrontal resting state brain function, resting state metabolic activities were compared and correlated with the Physical and Social Anhedonia Scale scores in 29 patients with schizophrenia and 21 healthy controls using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). In patients with schizophrenia, Physical Anhedonia Scale scores showed a trend-level negative correlation with the hypoactive dorsomedial prefrontal metabolism while Positive and Negative Symptom Scale (PANSS) negative subscale scores positively correlated with hyperactive cerebellar metabolism. Voxelwise correlation analysis showed physical anhedonia correlates in resting state activities of the supplementary motor area, ventromedial and dorsolateral prefrontal cortex, insular gyrus, and the precuneus in patients with schizophrenia while no frontal metabolic correlates were found in healthy controls. The hypoactive dorsomedial prefrontal metabolism correlated with physical anhedonia-correlated resting state regional activities. These findings provide further evidence for the relation of functional hypofrontality to the deficit syndrome and possible involvement of the functional imbalance in the cortico-cerebellar-thalamic-cortical circuit in the resting state brain function of schizophrenia. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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