Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 164, Issue 3, Pages 206-214Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2007.12.011
Keywords
Suicide; Self-aggression; Voxel-based morphometry; Volumetry
Categories
Funding
- Italian Ministry of Health [RC 06/A]
- European Union
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The neurobiology of suicidality in schizophrenia is largely unknown. We therefore assessed gray and white matter volumes associated with past suicidality and current self-aggression in schizophrenia. Fifty-five outpatients with schizophrenia (n=55) and healthy controls (n=55), matched for age, gender and handedness, were recruited. Ten patients had a life-time history of one or more suicide attempts. Current self-aggression was assessed using the Modified Overt Aggression Scale. High resolution structural magnetic resonance images were analyzed by voxel-based morphometry. We found significantly larger inferior frontal white matter volumes bilaterally in patients with a previous suicide attempt as compared with those patients without a history of suicidality. No other significant white or gray matter volume differences were observed. White matter volume in these regions did not differ between healthy controls and those patients without a previous suicide attempt. Furthermore, among patients, the level of current self-aggression showed a significant positive correlation with white matter volume in the same regions. Inferior frontal white matter alterations in fronto-temporo-limbic circuits may be associated with suicidality and self-aggression in schizophrenia. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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