Journal
PSYCHIATRY RESEARCH
Volume 269, Issue -, Pages 621-624Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2018.09.001
Keywords
Major depressive disorder; Epigenetic age; Brain
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Funding
- Hunan Provincial Innovation Foundation for Postgraduate [CX2016B064]
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A large body of evidence indicates major depressive disorder (MDD) associated with biological aging acceleration. In this study, we aim to assess epigenetic aging in different prefrontal sub-regions and cell types from postmortem tissues in MDD by using two public methylation datasets (subjects are 40 and 58 respectively). Results showed that brain epigenetic age has a strong correlation with chronological age in both datasets. However, there are no significant differences in epigenetic aging acceleration between MDD and controls in all prefrontal sub-regions and cell types. In conclusion, this study provides evidence against epigenetic aging acceleration in the brain in MDD.
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