Journal
PSYCHIATRY RESEARCH
Volume 200, Issue 2-3, Pages 784-788Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2012.07.031
Keywords
Child aggression; Genetics; Arginine vasopressin (AVP); AVPR1A; AVPR1B
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Funding
- CAMH Foundation
- Howitt/Dunbar Foundation and Youthdale Treatment Centres, Canadian Institute for Health Research
- American Foundation for Suicide Prevention
- Eli Lilly
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Background: Studies on animal models have implicated arginine vasopressin signalling pathway in aggressive behaviour. The role of arginine vasopressin in childhood onset aggression is unclear. Methods: We investigated 11 single-nucleotide polymorphisms in the genes coding for arginine vasopressin and its receptors in our sample of 177 aggressive child cases paired with adult controls matched for sex and ethnicity. Results: We found the non-synonymous polymorphism AVPR1B_rs35369693 to be associated with child aggression in our sample (P=0.007). We also found two-marker haplotype window containing AVPR1B_rs35369693 and AVPR1B_rs28676508 to be associated (P=0.003). The haplotype findings survived multiple-testing adjusted significance threshold a 0.0063. Conclusions: This is the first report of a genetic association between vasopressin receptor 1B and child aggression. Replication in independent samples are required to confirm these findings. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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