Journal
PSYCHIATRY RESEARCH
Volume 179, Issue 2, Pages 231-234Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2009.04.018
Keywords
Angiotensin; ACE I/D; Serotonin; 5-HIAA; Dopamine; HVA
Categories
Funding
- Lundberg Foundation
- Soderberg Foundation
- Bertil Hallsten Foundation
- Swedish Brain Foundation
- Swedish Brain Power Initiative
- Swedish Lundbeck foundation
- Swedish Research Council [8668, 2006-2992, 2006-986]
- Wallenberg Foundation
- HUBIN project
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Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin 1 to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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