Journal
PSYCHIATRY RESEARCH
Volume 178, Issue 2, Pages 342-347Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2010.04.003
Keywords
Cholecystokinin; Anxiety
Categories
Funding
- Estonian Science Foundation [7034]
- Ministry of Education of Estonia
- [SF0182590As03]
- [SF0180125s08]
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In this study we examined how personality disposition may affect the response to cholecystokinin tetrapeptide (CCK-4; 50 mu g) challenge in healthy volunteers (n = 105). Personality traits were assessed with the Swedish universities Scales of Personality (SSP). Statistical methods employed were correlation analysis and logistic regression. The results showed that the occurrence of CCK-4-induced panic attacks was best predicted by baseline diastolic blood pressure, preceding anxiety and SSP-defined traits of lack of assertiveness, detachment, embitterment and verbal aggression. Significant interactions were noted between the abovementioned variables, modifying their individual effects. For different subsets of CCK-4-induced symptoms, the traits of physical aggression, irritability, somatic anxiety and stress susceptibility also appeared related to panic manifestations. These findings suggest that some personality traits and their interactions may influence vulnerability to CCK-4-induced panic attacks in healthy volunteers. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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