Journal
PSYCHIATRY RESEARCH
Volume 169, Issue 1, Pages 12-15Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2008.06.017
Keywords
Repetitive transcranial magnetic stimulation; Depression; Prefrontal cortex; Response; Remission; Antidepressant
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Funding
- National Health and Medical Research Council (NHMRC)
- NARSAD
- NHMRC [436710]
- Neurosciences Australia Clinical Neurobiology of Psychiatry Platform
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The objective of this study was to explore the response rate to high-frequency left-sided repetitive transcranial magnetic stimulation (rTMS) in patients who had failed to respond to right-sided low-frequency stimulation, and to investigate whether there was differential efficacy between stimulation at 5 or 10 Hz. Data from two randomized controlled trials were pooled. In both studies a group of patients were randomized to receive either 5- or 10-Hz left prefrontal rTMS after failing to respond to right-sided stimulation. These patients received blinded 5- or 10-Hz stimulation (but without a sham control) for a period of up to 4 weeks and outcomes were compared. There was a small but significant overall response to left-sided rTMS but no difference in response between the 5- and 10-Hz treatment conditions. There appears to be a significant but modest likelihood of response to left-sided TMS in patients who fail right-sided stimulation, but there is no difference in efficacy between 5- and 10-Hz stimulation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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