Journal
PSYCHIATRY RESEARCH
Volume 168, Issue 3, Pages 193-197Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2008.05.008
Keywords
Eye movement; Antisaccade; Smooth pursuit; Neuropsychology; Schizophrenia
Categories
Funding
- Wellcome Trust
- Stanley Medical Research Institute
- Psychiatry Research Trust
Ask authors/readers for more resources
Impairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures. The relationship between performance on eye movement and neuropsychological tasks was measured in 79 schizophrenic patients (63% from Multiply affected families), 129 of their healthy first-degree relatives, and 72 normal controls. Antisaccade scores were correlated with most measures of neurocognitive functioning, and this correlation was strongest in schizophrenic patients in all cases. In the schizophrenic patients, but not their relatives or controls, the antisaccade distractibility error (ADE) score correlated significantly with current intelligence, verbal memory (immediate and delayed recall), and associative learning. In the case of crystallised IQ and delayed verbal memory, smaller correlations were present in unaffected relatives. although neither survived Bonferroni correction. Smooth pursuit performance was unrelated to any neuropsychological measure. Our study Suggests that antisaccade errors are likely to represent part of a generalized neuropsychological deficit in schizophrenia. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available