Journal
PSYCHIATRY RESEARCH
Volume 166, Issue 2-3, Pages 158-165Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2008.01.012
Keywords
Schizophrenia; Sex differences; Spatial abilities; Object location memory
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Funding
- NIMH NIH HHS [R01 MH052886-07, R01 MH052886] Funding Source: Medline
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Sex differences are pervasive in schizophrenia, ranging from differences in the age of onset and symptoms of the illness to structural brain differences. Yet, there has been very little research on the interaction of these differences with established cognitive sex differences that exist in healthy populations. We tested 25 patients with schizophrenia and 17 healthy controls on a two-dimensional task of object location memory. It has been previously shown that healthy females outperform healthy males on this task, a result that was upheld in this experiment. However, the female advantage is completely absent in patients with schizophrenia. This finding has important implications for the interpretation of clinical and physiological sex differences present in schizophrenia. (c) 2008 Elsevier Ireland Ltd. All fights reserved.
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