Journal
PSYCHIATRY RESEARCH
Volume 157, Issue 1-3, Pages 279-282Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2007.02.010
Keywords
marijuana; schizophrenia; event-related potentials
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Funding
- NIDA NIH HHS [R21 DA019672] Funding Source: Medline
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While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis users demonstrated increased P300 amplitudes for unpleasant trait words, and demonstrated higher positive syndrome schizotypy which correlated with levels of cannabis use. The cannabis group also exhibited lower negative syndrome schizotypy. The lack of blunted responses during the affect ERP and decreased negative subscale schizotypy scores provide evidence that the endocannabinoid theory of schizophrenia may be primarily relevant in relation to positive syndrome SZ. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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