Journal
PSYCHIATRY INVESTIGATION
Volume 7, Issue 1, Pages 68-71Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.4306/pi.2010.7.1.68
Keywords
Alzheimer's disease; cell cycle; Biomarker; Cell death; Peripheral lymphocytes
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Funding
- Choi Shin-Hai Neuropsychiatric Research Fund
- Ministry of Health Welfare [A040042, A060618]
- Korea government (MEST) [ROA 2007-000-20129-0]
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Objective We evaluated cell viability and proliferation activity of peripheral lymphocytes as potential models of neuronal death in Alzheimer's disease (AD). Methods We analyzed the cell viability and proliferation activity of phytohemagglutinin (PHA)-activated lymphocytes from 68 AD patients and 33 normal controls. The cellular measures were made at baseline (0 hr), 24 hrs, 48 hrs, 72 hrs, and 96 hrs after PHA stimulation. Results Cell viability in the AD patients was significantly decreased at 72 hrs and 96 hrs, compared with the normal controls. The declining ramp of the proliferation activity from 48 hrs to 72 hrs after PHA stimulation was significantly related to cell viability at 72 firs and at 96 hrs in the AD patients. Conclusion Lymphocytes from patients with AD have altered viability and proliferation characteristics in culture following PHA stimulation. These findings suggest that lymphocytes may be used as a peripheral tissue model of cell cycle dysregulation in AD. Psychiatry Investig 2010;7:68-71
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