Journal
PSYCHIATRY INVESTIGATION
Volume 6, Issue 3, Pages 216-221Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.4306/pi.2009.6.3.216
Keywords
Attention deficit hyperactivity disorder; Continuous performance test; Dopamine D4 receptor; 4 repeats allele; Commission errors
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Objective The aim of this study was to evaluate the association between a variable number of tandem repeats polymorphism at the dopamine D4 receptor gene (DRD4) and the performance of children with attention deficit hyperactivity disorder (ADHD) in a continuous performance test (CPT). Methods This study included 72 ADHD children (mean age=9.39 +/- 2.05 years) who were recruited from one child psychiatric clinic. The omission errors, commission errors, reaction time and reaction standardization in the CPT were computed. The number of 48-base pairs tandem repeats in the exon III of DRD4 was analyzed in a blind manner. Results The homozygosity of the 4-repeat allele at DRD4 was significantly associated with fewer commission errors (t=2,364, df=28.685, p=0.025) and standard deviation of reaction time (t=2.351, df=24.648, p=0.027) even after adjusting for age. The results of analyses of CPT measured values among three groups showed that the group with higher frequency of the 4-repeat allele showed a lower mean score of commission errors (F=4.268, df=2, P=0.018). Conclusion These results Suggest a protective role of 4-repeat allele of the DRD4 polymorphisms on commission errors in the CPT in children with ADHD.
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