Journal
PSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 64, Issue 3, Pages 268-273Publisher
WILEY
DOI: 10.1111/j.1440-1819.2010.02091.x
Keywords
duration of untreated illness; early intervention; fluvoxamine; major depressive disorder; treatment outcome
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labor and Welfare
- Japan Health Sciences Foundation
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Aims: The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode. Methods: A logistic regression was performed with DUI, sex, age at onset, and score for 17 items on the Hamilton Depression Rating Scale at the time of start of fluvoxamine treatment as the explanatory variables, and the response and the remission as the outcome variables. Results: Regression analysis showed significant association between the response and DUI (P < 0.0001), and between the remission and DUI (P < 0.0001), respectively. The remission rate gradually decreased with longer DUI. Conclusion: Early treatment of first depressive episodes is important because a shorter DUI implied better remission outcomes.
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