Journal
PSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 64, Issue 6, Pages 659-662Publisher
WILEY
DOI: 10.1111/j.1440-1819.2010.02152.x
Keywords
depression; dopamine synthesis; L-[beta-11C]DOPA; positron emission tomography; repetitive transcranial magnetic stimulation
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [16591124, 21659274]
- Ministry of Health, Labour, and Welfare of Japan [17A-5, 20B-1]
Ask authors/readers for more resources
We have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on central dopaminergic function in patients with depression using positron emission tomography with L-[beta-11C]DOPA, a ligand to assess the rate of endogenous dopamine synthesis. Eight patients were treated with 10-daily sessions of rTMS over the left dorsolateral prefrontal cortex. Positron emission tomography scanning was performed in each patient twice, before the first session and 1 day after the last session. Although four out of eight patients responded to rTMS, there were no changes in the striatal dopamine synthesis rate (k) following rTMS. These results suggest that chronic rTMS had a limited effect on the dopaminergic system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available