Journal
ANIMAL PRODUCTION SCIENCE
Volume 55, Issue 8, Pages 999-1004Publisher
CSIRO PUBLISHING
DOI: 10.1071/AN13389
Keywords
breeding value; somatic cell count
Categories
Funding
- Polish National Science Centre [N N311311535, N N311519040]
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Lactoferrin gene (LF) is regarded as one of the potential markers of mastitis susceptibility/resistance in dairy cattle. The study's aim was therefore, to investigate the feasibility of two single nucleotide polymorphisms (SNP), placed in the 5'-flanking region and 3'-untranslated region of the LF gene, to serve as mastitis markers. The associations between these SNP and the expression of LF, both onm RNA and protein level, were estimated in the milk of Polish Holstein-Friesian cows. The relationships between polymorphisms and cows' estimated breeding values (EBV) for somatic cell count were also calculated. It was shown that both polymorphisms have a significant impact on lactoferrin content in milk, and that LF+32 SNP is associated with the cow's EBV for somatic cell count. No association between SNP chosen for the study and lactoferrin mRNA abundance in milk somatic cells was observed. We propose LF+32 SNP for a molecular marker of mastitis resistance in dairy cows.
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