Journal
PSYCHIATRIC GENETICS
Volume 24, Issue 5, Pages 225-229Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YPG.0000000000000047
Keywords
CNR1; CNR2; schizophrenia; single-nucleotide polymorphism
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Funding
- Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A101023]
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0011935]
- National Research Foundation of Korea [2011-0011935] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Located on 6q15 and 1p36.11, cannabinoid receptor 1 (CNR1) and cannabinoid receptor 2 (CNR2) genes are considered to be a positional and functional candidate gene for the development of mental disorders such as schizophrenia because CNR1 is known as a regulator of dopamine signaling in the hippocampus and the cerebral cortex. However, few genetic studies have been carried out to investigate an association of CNR1 and CNR2 polymorphisms and the risk of schizophrenia. In this study, although the result indicates that CNR1 and CNR2 variations are unlikely to influence schizophrenia susceptibility in a Korean population, the findings would provide meaningful information for further genetic studies. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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