Journal
PSYCHIATRIC GENETICS
Volume 20, Issue 4, Pages 184-186Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YPG.0b013e32833a220b
Keywords
Ashkenazi; association; endophenotype; Jewish; reelin; schizophrenia; sex-specific
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Funding
- Johns Hopkins Brain Science institute
- National Institutes of Mental Health [RO1MH057314, RO1MH068406]
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A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case-control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype-phenotype correlations. Psychiatr Genet 20: 184-186 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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