Journal
PROTOPLASMA
Volume 249, Issue 2, Pages 223-238Publisher
SPRINGER WIEN
DOI: 10.1007/s00709-011-0282-5
Keywords
Trypanosoma brucei; Stress; Differentiation; Gene expression; Unfolded protein response; Heat shock
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Funding
- Wellcome Trust
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All organisms are able to modulate gene expression in response to internal and external stimuli. Trypanosomes represent a group that diverged early during the radiation of eukaryotes and do not utilise regulated initiation of transcription by RNA polymerase II. Here, the mechanisms present in trypanosomes to alter gene expression in response to stress and change of host environment are discussed and contrasted with those operating in yeast and cultured mammalian cells.
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