Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 2, Issue 12, Pages 1620-1627Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200800039
Keywords
Proneurotensin/neuromedin N; Serum-free conditioned medium; Small cell lung carcinoma; Tandem mass spectrometry; Tumor marker
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Proteins secreted from specific cancer cells have a high potential for use as tumor markers. We identified secreted proteins produced by 15 different carcinoma cell lines grown in serum-free medium using MS/MS. Proneurotensin/neuromedin N (proNT/NMN) was found in conditioned medium from four of seven small cell lung carcinoma cell lines but not from eight non-small cell lung carcinoma cell lines. These results indicate proNT/NMN has potential as a specific tumor marker of small cell lung carcinoma.
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