Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 2, Issue 10-11, Pages 1435-1443Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200800013
Keywords
Clinical; Imaging mass spectrometry; Tissue profiling
Funding
- NIH/NIGMS [2RO1 GM58008-09]
- NIH/NCI [CA068485-11]
- DOD [W81XWH-05-1-0179]
- [RO1 CA102353]
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Imaging MS (IMS) has emerged as a powerful tool for biomarker discovery. A key advantage of this technique is its ability to probe the proteome directly from a tissue section with preservation of the spatial relationships of the sample and minimal sample preparation. This allows for direct correlation of protein expression with histology. Here, we present the latest developments in imaging NIS and their relevance to clinical mass spectral analysis. IMS allows for high throughput analysis of tissue samples and is fully compatible with biostatistical analysis without prior knowledge of protein expression. Several studies are presented of applications in which direct tissue mass spectral analysis has provided insight into clinical questions not readily available by other means. Examples include the determination of lymph node status from investigation of primary breast tumors, prediction of response of breast tumors to chemotherapy, classification and prediction of progression of lung lesions, and exploration of 'molecular' margins in invasive disease.
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