Journal
PROTEOMICS
Volume 14, Issue 20, Pages 2242-2248Publisher
WILEY
DOI: 10.1002/pmic.201400249
Keywords
Alternative splicing; Bioinformatics; Domain-domain interaction; Protein-protein interactions; RNA-seq; Tissue-specific
Funding
- Senior Research Fellowship (SRF) from University Grants Commission (UGC), India
- CDFD
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The functional repertoire of genes in the eukaryotic organisms is enhanced by the phenomenon of alternative splicing. Hence, a node in a tissue specific protein-protein interaction (TS PPIN) network can be thought of as an ensemble of various spliced protein products of the corresponding gene expressed in that tissue. Here we demonstrate that the nodes that occupy topologically central positions characterized by high degree, betweenness, closeness, and eigenvector centrality values in TS PPINs of Homo sapiens are associated with high number of splice variants. We also show that the high centrality of these genes/nodes could in part be explained by the presence of a large number of promiscuous domains.
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