Journal
PROTEOMICS
Volume 15, Issue 5-6, Pages 903-914Publisher
WILEY
DOI: 10.1002/pmic.201400301
Keywords
C-terminal sequencing; C-terminomics; Degradomics; PTMs; Technology
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The C-terminus (where C is carboxyl) of a protein can serve as a recognition signature for a variety of biological processes, including protein trafficking and protein complex formation. Hence, the identity of the in vivo protein C-termini provides valuable information about biological processes. Analysis of protein C-termini is also crucial for the study of C-terminal PTMs, particularly for monitoring proteolytic processing by endopeptidases and carboxypeptidases. Although technical difficulties have limited the study of C-termini, a range of technologies have been proposed in the last couple of years. Here, we review the current proteomics technologies for C-terminal analysis, with a focus on the biological information that can be derived from C-terminomics studies.
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