Journal
PROTEOMICS
Volume 12, Issue 10, Pages 1478-1498Publisher
WILEY
DOI: 10.1002/pmic.201100563
Keywords
Biochemistry; History; Networks; Protein-protein interactions; Signaling pathways; Systems biology
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Today, it is widely appreciated that proteinprotein interactions play a fundamental role in biological processes. This was not always the case. The study of protein interactions started slowly and evolved considerably, together with conceptual and technological progress in different areas of research through the late 19th and the 20th centuries. In this review, we present some of the key experiments that have introduced major conceptual advances in biochemistry and molecular biology, and review technological breakthroughs that have paved the way for today's systems-wide approaches to proteinprotein interaction analysis.
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