Journal
PROTEOMICS
Volume 12, Issue 23-24, Pages 3510-3523Publisher
WILEY
DOI: 10.1002/pmic.201200300
Keywords
Host-pathogen interaction; Microbiology; Midgut; Saliva; Vector-borne diseases
Funding
- CNRS Interdisciplinaire MIE
- ANR Blanc KerARBO
- IRD Maturation Project
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Vector-borne diseases (VBDs) are defined as infectious diseases of humans and animals caused by pathogenic agents such as viruses, protists, bacteria, and helminths transmitted by the bite of blood-feeding arthropod (BFA) vectors. VBDs represent a major public health threat in endemic areas, generally subtropical zones, and many are considered to be neglected diseases. Genome sequencing of some arthropod vectors as well as modern proteomic and genomic technologies are expanding our knowledge of arthropodpathogen interactions. This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens. Proteomic studies have identified proteins and biochemical pathways that may be involved in molecular crosstalk in BFA-pathogen associations. Future work can build upon this promising start and functional analyses coupled with interactome bioassays will be carried out to investigate the role of candidate peptides and proteins in BFA-human pathogen associations. Dissection of the hostpathogen interactome will be key to understanding the strategies and biochemical pathways used by BFAs to cope with pathogens.
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