Journal
PROTEOMICS
Volume 10, Issue 6, Pages 1226-1229Publisher
WILEY
DOI: 10.1002/pmic.200900379
Keywords
Bioinformatics; Manual validation; MASCOT Distiller; MaxQuant; Protein inference; Quantitative proteomics
Funding
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- Research Foundation Flanders (FWO-Vlaanderen)
- Fund for Scientific Research Flanders (Belgium) [G.0077.06, G.0042.07]
- Concerted Research Actions [BOF07/GOA/012]
- Ghent University and the Inter University Attraction Poles [IUAP06]
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Manual validation of regulated proteins found in MS-driven quantitative proteome studies is tedious. Here we present Rover (http://genesis.ugent.be/rover), a tool that facilitates this process. Rover accepts quantitative data from different sources such as MASCOT Distiller and MaxQuant and, in an intuitive environment, Rover visualizes these data such that the user can select and validate algorithm-suggested regulated proteins in the frame of the whole experiment and in the context of the protein inference problem.
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