Journal
PROTEOMICS
Volume 10, Issue 23, Pages 4209-4212Publisher
WILEY
DOI: 10.1002/pmic.201000327
Keywords
Global protein analysis; Protein expression; Quantitative analysis; Shotgun proteomics; Systems biology
Funding
- NSF
- NIH [5R01AI075068]
- Welch [F1515]
- Packard Foundations [GM55962]
Ask authors/readers for more resources
Proteins play major roles in most biological processes as a consequence protein expression levels are highly regulated While extensive post transcriptional translational and protein degradation control clearly influence protein concentration and functionality it is often thought that protein abundances are primarily determined by the abundances of the corresponding mRNAs Hence surprisingly a recent study showed that abundances of orthologous nematode and fly proteins correlate better than their corresponding mRNA abundances We tested if this phenomenon is general by collecting and testing matching large scale protein and mRNA expression data sets from seven different species two bacteria yeast nematode fly human and rice We find that steady state abundances of proteins show significantly higher correlation across these diverse phylogenetic taxa than the abundances of their corresponding mRNAs (p = 0 0008 paired Wilcoxon) These data support the presence of strong selective pressure to maintain protein abundances during evolution even when mRNA abundances diverge
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available