Journal
PROTEOMICS
Volume 8, Issue 19, Pages 3947-3955Publisher
WILEY
DOI: 10.1002/pmic.200800120
Keywords
Integral membrane protein; Membrane protein enrichment; Sample preparation; Transmembrane domain
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Integral membrane proteins (IMPs) are difficult to identify, mainly for two reasons: the hydrophobicity of IMPs and their low abundance. Sample preparation is a key component in the large-scale identification of IMPs. In this review, we survey strategies for shotgun identification of IMPs by MS/MS. We will discuss enrichment, solubilization, separation, and digestion of IMPs, and data analysis for membrane proteomics.
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